GUT DYSBIOSIS WAS INEVITABLE, BUT TOLERANCE WAS NOT: TEMPORAL RESPONSES OF THE MURINE MICROBIOTA THAT MAINTAIN ITS CAPACITY FOR BUTYRATE PRODUCTION CORRELATE WITH SUSTAINED ANTINOCICEPTION TO CHRONIC MORPHINE

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which Alpha-GPC necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates toleranc

BackgroundR3HDM1, an RNA binding protein with one R3H domain, remains uncharacterized in terms of its association with tumor progression, malignant cell regulation, and the tumor immune microenvironment.This paper aims to fill this gap by analyzing the potential of R3HDM1 in diagnosis, prognosis, chemotherapy, and immune function across various can

Granulomatous cheilitis (GC) of Miescher is a chronic inflammatory disorder of unknown etiology affecting Sports Repair Labor - Sharpening - Figure young adults, characterized by asymptomatic, unrelenting swelling of lips.An array of treatment modalities have been tried, only for the disease to recur again.We report a case of GC with significant re

The prevalence of diabetes mellitus in acromegaly is significantly higher than that in the general population.Carbohydrate metabolism abnormalities often precede other phenotypic manifestations of acromegaly.The review presents data on the prevalence of carbohydrate RED BEET ORG metabolism disorders in acromegaly and describes their pathophysiologi